You play as Riley Weston, a young man who tries an experimental serum developed by his friend Jill, and inadvertently ends up turning into a girl. Riley and his friends quickly begin to accept the change, but little do they know, there are strange, nefarious forces at work in the shadows, and events already set in motion that none of them could've predicted, including a mysterious scientist and her loyal right-hand with twisted motives that threaten more than just Riley's life...