In Neuro/Splice, we follow dual protagonists Cassie Marlowe and Ryke Voss, two sworn enemies of opposing factions. Cassie belongs to the Veilbreakers - an outlawed group of truth-seekers who are convinced that NexaCorp is hiding something profoundly important about the state of the known world. Ryke works for NexaCorp, as a police officer, and has a personal reason to take down Cassie and the Veilbreakers.
The Veilbreakers successfully plant a computer virus in the NexaCorp mainframe, threatening to spill the corporate secrets to the world, before triggering a catastrophic meltdown. The culprits straight-up refuse to reveal how to safely remove it, and time is running out... Ryke and his team form a mad plan: Infiltrate the mixed-gender maximum security prison where Clyde and Eric are held, pretending to be Cassie, and learn the truth about the virus. To do so, they need to use an experimental procedure known as Neuro-Splicing, transferring Ryke's consciousness into Cassie's body.
Ryke (in Cassie's body) is thrown into prison, and a dangerous underground world, in an attempt to learn how to stop the virus. Inevitably he stumbles upon truths about NexaCorp that makes him question everything he knows. Meanwhile, Cassie wakes up in Ryke's body and finds herself in a unique position of power to learn more about the NexaCorp from within its own ranks...