Cause of Death is a visual novel that is divided into a series of sixteen volumes, each of which is made up of eight chapters (excluding the first, fourteenth and sixteenth volumes).
Follow protagonists Mal Fallon and Natara Williams, an SFPD detective and an FBI Special Agent respectively, as they hunt down serial killers and members of organized crime who put the safety of the city at risk.
Featuring a plot inspired by crime scene investigation television shows and is based upon solving murder mysteries, prominent themes include friendship, love, trust, morality and criminology. The story takes place mostly in San Francisco, although some there are a handful of situations that take place in other areas.